Stemolecule™ PD0325901 生化試劑
簡要描述：
Stemolecule™ PD0325901（MEK抑制劑）：PD0325901是一種靶向MAPK（MAPK/ERK kinase 或MEK）的小分子，具潛在的抗腫瘤活性。
產(chǎn)品時間：2023-02-15
打印當前頁Stemolecule™ PD0325901（MEK抑制劑）
產(chǎn)品關(guān)鍵詞：
MEK；na?ve stem cells 初始干細胞；neural progenitor cells 神經(jīng)祖細胞；WH-4-023；CHIR99021；CAS：391210-10-9；
產(chǎn)品描述：
PD0325901是一種靶向MAPK（MAPK/ERK kinase 或MEK）的小分子，具潛在的抗腫瘤活性。PD0325901是MEK抑制劑CI-1040的衍生物，選擇性結(jié)合和抑制MEK，可能引起MAPK/ERK的磷酸化和活化，抑制腫瘤細胞增殖。與ALK5抑制劑SB431542一起，PD0325901能夠提高人原代成纖維細胞重編程為誘導(dǎo)多潛能干細胞（iPS）的能力。
Stemgent公司提供支持初始潛能干細胞應(yīng)用需要的5i/L/A培養(yǎng)基添加劑（5i/L/A media supplment）所有成分，如下：
名稱 | 貨號 | 規(guī)格 |
Stemolecule™ WH-4-023 SRC Inhibitor | 04-0079 | 2 mg |
Stemolecule™ SB590885 BRAF Inhibitor | 04-0080 | 2 mg |
Stemolecule™ IM-12 GSK-3β Inhibitor | 04-0081 | 2 mg |
Stemolecule™ PD0325901 MEK Inhibitor | 04-0006 | 2 mg |
Stemolecule™ Y27632 ROCK Inhibitor | 04-0012 | 2 mg |
Stemfactor™ LIF, Human Recombinant | 03-0016 | 1 ml, 10 μg/ml |
Stemfactor™ Activin A, Human Recombinant | 03-0001 | 5 μg |
產(chǎn)品特性
同義名：N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide
分子式：C16H14F3IN2O4
分子量：482.19 g/mol
CAS NO: 391210-10-9
純度：＞97%（HPLC）
外觀：Pale purple solid
溶解性：DMSO
保存和穩(wěn)定性：粉末4 °C避光保存，重溶后的儲存液分裝后-20 °C保存，6個月穩(wěn)定。
質(zhì)量控制：HPLC測定純度，MS測定準確分子量，PD0325901對小鼠胚胎干細胞的細胞毒性測試。
結(jié)構(gòu)圖：
訂購信息：原裝好貨，歡迎訂購，：，：。
品牌 | 名稱 | 貨號 | 規(guī)格 |
Stemgent | Stemolecule™ PD0325901 MEK Inhibitor | 04-0006 | 2 mg |
Stemgent | Stemolecule™ PD0325901 MEK Inhibitor | 04-0006-10 | 10 mg |
Stemgent | Stemolecule™ PD0325901 in Solution | 04-0006-02 | 2 mg (10 mM) |
引用文獻：
Han Y-C, Lim Y; Duffieldl MD; Liu J; Manaph NPA; Yang M; Keating DJ; Zhou X-F. "Direct reprogramming of mouse fibroblasts to neural stem cells by small molecules." Stem Cells International 2016:4304916 (2016)
Liu G. "No detection of potential cancer risk for free-viral reprogrammed stem cell-derived dopaminergic neurons from adult mice fibroblasts." J Stem Cell Res Ther 5:286 (2015)
Ren J; Briones V; Barbour S; Yu W; Han Y; Tarashima M; Muegge K. "The ATP binding site of the chromatin remodeling homolog LSH is required for nucleosome density and de novo DNA methylation at repeat sequences." Nucl Acids Res doi: 10.1093/nar/gku1371 (2015)
DeRosa BA; Belle KC; Thomas BJ; Cukier HN; Pericak-Vance MA; Vance JM; Dykxhoom DM. "hVGAT-mCherry: A novel molecular tool for analysis of GABAergic neurons derived from human pluripotent stem cells." Mol Cell Neurosci 68:244 (2015)
Ying, Q., Tai, C. Gbx2, a LIF/Stat3 target, promotes reprogramming to and retention of the pluripotent ground state. Journal of Cell Science 126, 1093 – 1098.(2013)
Moraveji S-F; Attari F; Shahverdi A; Sepehri H; Farrokhi A; Hassani S; Fonoudi H; Aghdami N; Baharvand H. "Inhibition of glycogen synthase kinase-3 promotes efficient derivation of pluripotent stem cells from neonatal mouse testis." Human Reproduction 27:2312 (2012)
Chiang P-M; Wong PC. "Differentiation of an embryonic stem cell to hemogenic endothelium by defined factors: Essential role of bone morphogenetic protein 4." Development 138: 2833-2843 (2011)
Nagy, K., Sung, H-K., Zhang, P., Laflamme, S., Vincent, P, Agha-Mohammadi, S., Woltjen, K., Monetti, C., Michael, I. P., Smith, L. C., Nagy, A. Induced Pluripotent Stem Cell Lines Derive from Equine Fibroblasts. Stem Cell Reviews and Reports 7:693 (2011).
Wang, B., Miyagoe-Suzuki, Y., Yada, E., Ito, N., Nishiyama, T., Nakamura, M., Ono, Y., Motohashi, N., Segawa, M., Masuda, S., Takeda, S. Reprogramming Efficiency and Quality of Induced Pluripotent Stem Cells (iPSCs) Generated from Muscle-derived Fibroblasts of MDX Mice at Different Ages. PLOS Currents Muscular Dystrophy. 2011 Oct 27 . Edition 1. doi: 10.1371/currents.RRN1274 .
Mack, A., Kroboth, S., Rajesh, D., Wang, W. B. Generation of Induced Pluripotent Stem Cells from CD34+ Cells across Blood Drawn from Multiple Donors with Non-Integrating Episomal Vectors. PLoS One; 6(11): e27956.(2011)
Li, W., Zhou, H., Abujarour, R., Zhu, S., Young Joo, J., Lin, T., Hao, E., Sch?ler, H.R., Hayek, A., Ding, S. (2009) Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2. Stem Cells 27: 2992-3000.
Ying, Q.L., Wray, J., Nichols, J., Batlle-Morera, L., Doble, B., Woodgett, J., Cohen, P., and Smith, A. (2008) The ground state of embryonic stem cell self renewal. Nature 453: 519-523.
— —Written/Edited by V. Shallan【版權(quán)歸MKBio懋康所有】
上海懋康生物科技有限公司是一家涉足于生命科學(xué)和生物技術(shù)領(lǐng)域研究的試劑、儀器和實驗室消耗品與實驗服務(wù)工作，主要從事細胞生物學(xué)、植物學(xué)、分子生物學(xué)、免疫學(xué)、生物化學(xué)、蛋白組學(xué)。生物制藥與診斷試劑研發(fā)生產(chǎn)等領(lǐng)域。 本公司秉承“以人為本，以誠為信、合同守信"的經(jīng)營理念。堅持"品質(zhì)保障"的原則為廣大客戶提供優(yōu)質(zhì)產(chǎn)品。
Stemolecule™ PD0325901（MEK抑制劑）
Stemolecule™ PD0325901（MEK抑制劑）
Stemolecule™ PD0325901（MEK抑制劑）